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doi: 10.1016/S2213-2600(20)30076-X 6 PoteyPMRossiAGLucasCDDorwardDA

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The combination therapy was more effective in up-regulating the perforin-expressing effector CD8 + T cells and down-regulating the myeloid-derived suppressor cells, thus is considered effective cancer treatment [171]

This supports the clinical use of arginine depletion as anti-cancer therapy but its exact efficacy in various cancers requires further investigation